Subacute sclerosing panencephalitis (SSPE) in Papua New Guinea: a high incidence in young children

Subacute Sclerosing Panencephalitis in Iran

Subacute sclerosing panencephalitis (SSPE) associated with congenital measles infection.

A 13-month-old male presented with repetitive episodes of myoclonic jerks of the head and extremities for two months. His past medical history revealed that his non-immunized mother had measles at the time of delivery. Measles antibody titers in serum and cerebrospinal fluid (CSF) were 1/512 (hemagglutinin inhibition [HI]) and 1/128 HI, respectively. Immunofixation electrophoresis of CSF reveal...

Subacute Sclerosing Panencephalitis (SSPE) - due to Lack of Complete Immunization?

The child was admitted in the paediatric department with complaints of fits for one month and altered level of consciousness for two days prior to admission. Mother had also noticed changes in behaviour for one month. He became unusually frightened when he was alone and in a dark room. Fits were not controlled for two days when he came to Abbasi Shaheed hospital and child became drowsy. He was ...

Subacute Sclerosing Panencephalitis in Papua New Guinean Children: The Cost of Continuing Inadequate Measles Vaccine Coverage

INTRODUCTION subacute sclerosing panencephalitis (SSPE) is a late, rare and usually fatal complication of measles infection. Although a very high incidence of SSPE in Papua New Guinea (PNG) was first recognized 20 years ago, estimated measles vaccine coverage has remained at ≤ 70% since and a large measles epidemic occurred in 2002. We report a series of 22 SSPE cases presenting between Novembe...

Epilepsy in children with subacute sclerosing panencephalitis.

INTRODUCTION Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, fatal neurodegenerative disease of childhood and early adolescence caused by defective measles virus. The initial symptoms of SSPE usually involve regression in cognitive functioning and behavior or recurrent myoclonic jerks. Seizures revealing SSPE and epilepsy during the clinical course can occur. OBJECTIVE The ...